Anti-HUS1 Antibody

HUS1 is a core subunit of the Rad9-Hus1-Rad1 (9-1-1) clamp complex that loads onto damaged DNA and activates ATR-dependent checkpoint signaling during the cellular response to genotoxic stress. This rabbit polyclonal antibody from Antibodies.com recognizes the human, mouse, and rat HUS1 protein and is suited to western blot, immunohistochemistry, and immunofluorescence workflows in research laboratories. Supplied as 100 µl of unconjugated antiserum, the reagent supports detection of endogenous Hus1 across cultured mammalian cells and tissue sections, where nuclear localization at stalled replication forks and DNA lesions can be examined. Aliquot upon arrival to limit freeze-thaw cycles; for storage, refrigerate at 4 °C for short-term use or freeze at -20 °C for longer term. Pairing with appropriate HRP- or fluorophore-conjugated secondary reagents enables studies of checkpoint activation, replication fork stability, and DNA damage response pathways implicated in cancer biology and aging research.