Anti-HTT Antibody

Affinity-purified reagent for visualizing huntingtin protein distribution in rat tissue sections. Generated in rabbit hosts and supplied as an unconjugated IgG preparation, this polyclonal antibody binds the HTT gene product, the protein whose expanded polyglutamine tract underlies Huntington's disease pathology. Researchers studying neurodegenerative disease models rely on it for immunohistochemistry workflows that map huntingtin localization in brain slices, where the antibody marks cytoplasmic and nuclear staining patterns characteristic of the endogenous protein. The 200 µl vial volume supports multiple staining runs on slide-mounted sections, and the unconjugated format lets users pair it with their preferred secondary detection reagents. Reactivity has been validated against rat samples, making the reagent directly applicable to rodent studies of striatal neuron vulnerability, inclusion body formation, and mutant huntingtin aggregation dynamics. Best results are obtained on perfusion-fixed tissue processed with standard antigen retrieval protocols. Supplied by Antibodies.com as part of the Primary Antibodies lineup.