Anti-HSPA5 Antibody

Raised in rabbit hosts and supplied as a 100 µl polyclonal antiserum from Antibodies.com, this unconjugated reagent targets HSPA5 (also called BiP or GRP78), the ~78 kDa endoplasmic reticulum chaperone that governs the unfolded protein response. It cross-reacts with Human, Mouse, and Rat samples and is validated for Western blot and immunohistochemistry, supporting comparative work across human tissues and rodent disease models.

HSPA5 transcription and translation rise sharply when misfolded proteins accumulate in the ER lumen, so the antibody is widely deployed as a marker of ER stress in cancer biology, neurodegeneration, and metabolic disease research. Investigators commonly pair it with chemical inducers such as tunicamycin or thapsigargin to confirm engagement of the unfolded protein response. The polyclonal format increases the chance of recognising multiple epitopes on the target, which is helpful in denatured western blot lysates and fixed IHC sections.

Supplied in a vial for refrigerated storage, the unconjugated antibody can be labelled with HRP, biotin, or a fluorophore to suit custom detection chemistry. Antibodies.com lists the product within the Primary Antibodies category, with reactivity covering human, mouse, and rat species. Aliquoting on first use helps limit repeated freeze-thaw cycles and preserves titre over long-term studies.