Anti-HSPA1A Antibody

Raised in rabbit, this polyclonal antibody from Antibodies.com targets HSPA1A, the stress-inducible 70 kDa heat shock protein (Hsp70) that acts as a molecular chaperone in protein folding, refolding, and cytoprotection under thermal, oxidative, and proteotoxic stress. The unconjugated reagent is supplied as 100 µl and has been validated for Western blot (WB) and immunofluorescence (IF) workflows on human samples, supporting studies of heat shock responses, chaperone networks, and stress-related signaling in cell biology and disease research.

HSPA1A localizes primarily to the cytoplasm and nucleus under basal conditions and is rapidly upregulated by cellular stress, making it a useful marker for examining stress responses and chaperone-mediated protein homeostasis. As a polyclonal reagent, the antibody recognizes multiple epitopes on HSPA1A, which can improve detection across denatured Western blot and fixed-cell immunofluorescence preparations. The unconjugated format allows flexible pairing with secondary antibodies or custom labeling for co-localization studies and protein expression analysis.