Anti-HSP60 Antibody

Heat shock protein 60 (HSP60) is a mitochondrial chaperonin of approximately 60 kDa that mediates the ATP-dependent folding of client proteins imported into the mitochondrial matrix. Because altered HSP60 expression has been linked to mitochondrial dysfunction, chaperoninopathies, autoimmune responses, atherosclerosis, and tumor cell survival, reliable detection reagents for this target are widely used in cell biology, neuroscience, and translational disease research.

This rabbit polyclonal antibody from Antibodies.com is supplied as an unconjugated reagent in a 100 µl volume and has been validated for western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) workflows. The antibody recognizes endogenous HSP60 in human, mouse, and rat samples, supporting comparative studies across standard mammalian model systems and patient-derived specimens.

Investigators studying mitochondrial biogenesis, oxidative or thermal stress responses, chaperone-assisted protein refolding, and the crosstalk between mitochondria and inflammation can use this reagent to probe lysates, fixed tissue sections, and cultured cells. The polyclonal format offers multi-epitope coverage, which is advantageous when a single linear determinant is masked by sample processing, fixation, or post-translational modification of the native antigen.