Anti-HSF1 (Ab-307) Antibody

HSF1 (Heat Shock Factor 1) is the master transcriptional regulator of the cellular heat shock response in humans. This unconjugated rabbit polyclonal reagent from Antibodies.com binds an epitope within the region of residue 307 of human HSF1, supporting studies of stress-induced and basal transcription factor activity in research samples.

Validated applications include Western Blot for resolving HSF1 from cell lysates and Immunohistochemistry for localizing expression in formalin-fixed tissue sections. The antibody is raised in rabbit, prepared as a polyclonal antibody, and supplied at 100 µL per vial to permit flexible pairing with secondary reagents, fluorophores, and enzyme conjugates.

Reactivity is established against human HSF1, a stress-responsive transcription factor that drives HSP70 and other molecular chaperone expression under heat, oxidative, and proteotoxic stress. Investigators of cancer cell stress adaptation, neurodegeneration models, and thermotolerance pathways commonly rely on HSF1 antibodies directed at this region of the protein.

The polyclonal format offers broad epitope recognition useful for capturing HSF1 across varying expression levels and post-translational modification states within the heat shock regulatory network, and the unconjugated presentation allows researchers to build custom detection workflows.