Anti-HSD17B8 Antibody

Generated in rabbit and affinity-purified against hydroxysteroid 17-beta dehydrogenase 8, this unconjugated polyclonal primary antibody from Antibodies.com targets a mitochondrial oxidoreductase that participates in steroid hormone interconversion and in the mitochondrial fatty acid elongation pathway. The reagent is supplied at 100 µl per vial and is validated for Western blot and immunohistochemistry on human samples, providing a flexible tool for studying endogenous HSD17B8 expression in both cell lysates and fixed tissue sections.

Because HSD17B8 sits at the intersection of estrogen and androgen metabolism, fatty acid biosynthesis, and mitochondrial function, loss-of-function variants in the gene have been investigated in the context of neurodevelopmental phenotypes, including forms of X-linked intellectual disability in which disrupted enzyme activity has been reported. The antibody therefore serves researchers studying steroidogenic tissue biology, metabolic disorders, and the molecular basis of inherited neurodevelopmental conditions.

The polyclonal format offers broader epitope coverage than monoclonal alternatives and accommodates diverse detection chemistries, since the antibody is supplied unconjugated and can be paired with HRP, fluorescent, or biotinylated secondary reagents as required. Store the vial frozen, aliquot on first thaw to limit freeze-thaw cycles, and protect from light. Intended for research use only.