Anti-HSD11B1 Antibody

HSD11B1 encodes 11β-hydroxysteroid dehydrogenase type 1, an NADPH-dependent microsomal enzyme anchored in the endoplasmic reticulum that converts cortisone into active cortisol. This unconjugated rabbit polyclonal reagent from Antibodies.com targets the human protein and is supplied as 100 µl of polyclonal antiserum validated for western blot and immunofluorescence workflows. Researchers investigating glucocorticoid metabolism, adipocyte differentiation, hepatic gluconeogenesis, and 11β-HSD1-related pharmacology - including studies with inhibitors such as carbenoxolone - use this reagent to localize expression in liver, adipose, and neural tissue samples. The antibody supports research into type 2 diabetes, obesity, metabolic syndrome, and inflammatory pathways where dysregulated cortisol amplification drives disease progression. Suited to fixed-cell and frozen tissue preparations, the reagent provides a tool for mapping HSD11B1 protein levels across normal and disease-relevant specimens.