Anti-Hrs Antibody

Researchers studying membrane receptor trafficking through the endolysosomal system rely on affinity-purified polyclonal reagents targeting early endosome components such as Hrs (also known as HGS, hepatocyte growth factor-regulated tyrosine kinase substrate). The 50 µl unconjugated preparation offered by Antibodies.com is validated for western blot and ELISA applications across human, mouse, and rat samples.

Hrs acts as an early-acting component of the ESCRT machinery, binding ubiquitinated cargo via its FYVE and ubiquitin-binding domains and routing activated receptor tyrosine kinases into multivesicular bodies destined for lysosomal degradation. Laboratories investigating EGFR internalization, cytokine receptor turnover, and intraluminal vesicle biogenesis use this reagent to detect endogenous Hrs in cell lysates.

The polyclonal format recognizes multiple epitopes on the target, a useful property when probing post-translational modifications such as tyrosine phosphorylation that accompany growth factor signaling. Compatibility with standard immunoblotting membranes and ELISA plate-based assays permits the same aliquot to be deployed across orthogonal readouts when characterizing novel regulators of endosomal sorting.