Anti-Hrs Antibody

This rabbit polyclonal antibody targets Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate), a key component of the ESCRT machinery that mediates receptor sorting at early endosomes and the formation of multivesicular bodies. Antibodies.com supplies the reagent as 100 µl of unconjugated antiserum, applied in western blot and ELISA workflows with human, mouse, and rat samples. Hrs participates in ubiquitin-dependent cargo recognition, directing activated growth factor receptors toward lysosomal degradation rather than recycling back to the plasma membrane. Researchers studying EGF receptor down-regulation, viral budding, autophagosome maturation, or endosomal signaling pathways use this reagent to immunoprecipitate or detect endogenous Hrs protein in cell lysates. As a polyclonal preparation raised in rabbit, the antibody recognizes multiple epitopes on the target, providing reliable signal in western blot analysis where conformational flexibility matters.