Anti-Hrs Antibody

This rabbit polyclonal antibody from Antibodies.com targets Hrs (Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate), an approximately 86 kDa endosomal sorting protein that contains a FYVE zinc-finger domain and functions as a core component of the ESCRT-0 complex. Hrs recognizes ubiquitinated transmembrane cargo on early endosomal membranes and drives sorting into multivesicular bodies, a process central to attenuating receptor tyrosine kinase signaling, including ligand-induced EGFR downregulation.

The unconjugated antibody is supplied in a 100 µl volume and is validated across several research workflows: Western blot detection of endogenous Hrs in whole-cell lysates, immunohistochemistry on formalin-fixed tissue sections, immunofluorescence localization to early endosomal compartments, and ELISA-based quantitative assays. Reactivity has been confirmed with Human, Mouse, and Rat samples, enabling side-by-side comparison across standard mammalian model systems.

Because Hrs sits at the intersection of endocytic trafficking and signal termination, the reagent is a useful marker for researchers studying receptor internalization, lysosomal degradation, viral budding mechanisms that exploit ESCRT machinery, and the molecular basis of neurodegenerative or immunological disorders linked to defective endosomal sorting. Store refrigerated at 4°C in working aliquots to preserve polyclonal antibody stability over repeated use.