Anti-HPSE Antibody

Primary antibodies raised against the HPSE endoglycosidase serve as core reagents in laboratories investigating extracellular matrix turnover. The unconjugated rabbit polyclonal IgG reagent supplied by Antibodies.com is delivered as a 50 µl single-use vial and is validated for Western blot detection of full-length pro-heparanase (~65 kDa) and the processed active ~50 kDa subunit in cell lysate preparations.

Biochemically, heparanase is an endo-β-D-glucuronidase that cleaves heparan sulfate side chains of heparan sulfate proteoglycans, a step central to extracellular matrix remodeling, angiogenesis, cell migration, and the release of growth factors sequestered in the glycocalyx. Cross-reactivity across human, mouse, and rat samples enables comparative oncology, inflammatory disease modeling, and glycobiology workflows that span rodent model systems and human tissue validation.

For stability, refrigerate the vial at 4 °C on arrival and aliquot to limit freeze-thaw cycles; long-term storage at -20 °C is recommended for unused material. The reagent is intended for research use only and supports tumor invasion studies, wound healing assays, and investigations into matrix metalloproteinase cross-talk.