Anti-HPS1 Antibody

Raised in rabbit against the HPS1 target, this unconjugated polyclonal reagent from Antibodies.com is supplied as 100 µl of polyclonal antiserum validated for Western blot and immunofluorescence workflows on human samples. HPS1 encodes a transmembrane subunit of the BLOC-3 adaptor complex that drives cargo trafficking into lysosome-related organelles, so biallelic loss-of-function variants underlie the oculocutaneous albinism, pulmonary fibrosis, and platelet dense granule deficiency characteristic of Hermansky-Pudlak syndrome type 1. The unconjugated format lets laboratories pair this primary antibody with their own HRP-conjugated, fluorophore-conjugated, or biotinylated secondary reagents, which is useful when a single target needs to be detected across blots, fixed-cell imaging, and immunoprecipitation experiments. Researchers probing melanosome biogenesis, dense granule formation, retinal pigment epithelial biology, or fibrotic signaling in alveolar cells rely on consistent HPS1 detection in lysates and fixed monolayers. Storage at 4 °C in aliquots preserves activity across multiple freeze-thaw cycles, and 100 µl supports dozens of immunofluorescence coverslips or several Western blot membranes depending on dilution. The host species, clonality, and reactivity profile make this reagent a practical choice for laboratories building panels against trafficking machinery in the endolysosomal system.