Anti-HP1 alpha Antibody

The Anti-HP1 alpha polyclonal antibody from Antibodies.com is raised in rabbit and recognizes human heterochromatin protein 1 alpha (HP1 alpha), a chromodomain-containing protein encoded by the CBX5 gene. HP1 alpha selectively binds methylated histone H3 (H3K9me3) and concentrates at pericentromeric heterochromatin, making it a key marker in studies of gene silencing, nuclear architecture, and epigenetic regulation. Supplied as 50 µg of unconjugated liquid IgG in a vial, the reagent is validated for western blot and immunofluorescence on human samples. For chromatin immunoprecipitation and immunostaining workflows, aliquot the antibody and store at -20°C, avoiding repeated freeze-thaw cycles to preserve binding activity.