Anti-Hox-C6 Antibody

This unconjugated rabbit polyclonal antibody from Antibodies.com specifically recognizes the HoxC6 homeodomain transcription factor, a member of the HOX gene family that regulates anterior-posterior patterning during embryogenesis and is reactivated in several adult malignancies. The reagent is supplied at 100 µl per vial and validated for Western blot, immunohistochemistry, immunofluorescence, and ELISA workflows. Cross-reactivity has been confirmed against human and mouse samples, supporting studies in xenograft and syngeneic model systems as well as patient-derived tissue specimens.

HoxC6 has been most extensively characterized in prostate cancer research, where elevated expression correlates with tumor progression, and has been linked to chemoresistance in lung and esophageal carcinoma models. The homeodomain DNA-binding motif makes the protein a useful marker for tracking developmental lineage commitment in neural and mesodermal progenitors. For long-term use, aliquot upon receipt and store at -20 °C in working volumes to limit freeze-thaw cycles and protect the reagent from degradation.