Anti-HNRNPCL1 Antibody

This Rabbit polyclonal reagent from Antibodies.com is raised against a synthetic peptide spanning amino acids 200 to the C-terminus of human HNRNPCL1 (UniProt O60812). Affinity-purified and supplied as a 100 µl liquid aliquot in PBS pH 7.3 with 50% glycerol and 0.02% sodium azide, the unconjugated IgG detects the 32 kDa hnRNP C-like-1 protein in western blot (recommended dilution 1:500–1:1,000) and immunohistochemistry on human, mouse, and rat samples.

HNRNPCL1 is a primate-restricted retrogene of the HNRNPC family, containing a single RNA recognition motif (RRM) domain. The encoded protein localises to the nucleus and nucleoplasm as a component of ribonucleosomes and is implicated in pre-mRNA processing, splice site recognition, and ribonucleoprotein particle assembly, with a proposed role in nucleosome assembly through neutralisation of basic core hnRNPs. Researchers commonly use this reagent to dissect pre-mRNA splicing regulation, profile paralogue expression across tissues, validate HNRNPCL1 transcriptomics datasets, and confirm HNRNPCL1 levels in normal versus transformed cells.

The vial is shipped cold and should be aliquoted upon arrival, then stored at -20 °C with freeze-thaw cycles avoided to preserve binding activity across extended experiments. For research use only.