Anti-hnRNP K Antibody

Rabbit Polyclonal Antibody Targeting hnRNP K

This unconjugated polyclonal reagent, raised in rabbit against the heterogeneous nuclear ribonucleoprotein K (hnRNP K) RNA-binding protein, supports studies of transcriptional regulation, pre-mRNA splicing, translational control, and chromatin remodeling in eukaryotic cells. The product ships as 100 µl of antiserum, with specificity confirmed by Western blot on whole-cell lysates and by immunohistochemistry on tissue sections.

hnRNP K operates downstream of Src-family and PKC kinases, modulates p53 stress responses, and partners with c-Myc to regulate proliferation-associated transcripts. Antibodies.com supplies this reagent for laboratories investigating cancer cell signaling, RNA-processing factor dynamics, and neurodegenerative disease models. Validated research applications include ELISA, immunoprecipitation of native ribonucleoprotein complexes, chromatin immunoprecipitation, RNA pull-down, and immunofluorescence microscopy across human, mouse, and rat specimens.

The reagent is unconjugated, allowing pairing with HRP, alkaline phosphatase, biotin, or fluorophore-conjugated secondary antibodies. For routine use, store at -20°C in working aliquots to limit freeze-thaw cycles and protect from light when used in fluorescent workflows. Each lot is screened against the broader hnRNP family to confirm restricted reactivity to the K isoform.