Anti-hnRNP C1 / C2 Antibody

The heterogeneous nuclear ribonucleoproteins C1 and C2 (hnRNP C1/C2) are abundant nuclear RNA-binding proteins that play central roles in pre-mRNA processing, including splicing regulation, 3' end processing, and packaging of nascent transcripts. These related proteins are produced from a single gene through alternative splicing and are commonly used as reference markers for nuclear integrity in cell biology research.

This unconjugated rabbit polyclonal reagent from Antibodies.com targets the C1/C2 pair and is validated for Western blot, immunohistochemistry, and immunofluorescence workflows. Reactivity has been demonstrated against human, mouse, and rat samples, supporting studies across common mammalian model systems. The antibody is supplied as 100 µl of liquid, ready for dilution into standard buffers for blotting or staining protocols.

hnRNP C1/C2 are frequently investigated in the context of alternative splicing regulation, RNA-protein interaction mapping, telomere maintenance through association with the shelterin complex, and the cellular response to stress. The polyclonal format provides recognition of multiple epitopes within the C1/C2 proteins, which is useful when studying post-translational modifications such as sumoylation and methylation that influence hnRNP function and nuclear localization. For research use only.