Anti-hnRNP C1 / C2 Antibody

Supplied as 100 µl of unconjugated rabbit antiserum, this polyclonal antibody from Antibodies.com targets heterogeneous nuclear ribonucleoproteins C1 and C2, two closely related core components of hnRNP particles that bind nascent pre-mRNA and influence splicing, 3'-end processing, mRNA stability, and translation. The reagent recognizes both the ~41 kDa C1 isoform and the ~44 kDa C2 splice variant, which arise from the same HNRNPC transcript and differ by a 13-amino-acid insertion in C2. Validated applications include Western blot, immunohistochemistry, immunofluorescence, and ELISA, with reactivity confirmed against human, mouse, and rat samples. Refrigerate upon arrival and avoid repeated freeze-thaw cycles to preserve antibody titre. The reagent is commonly used in studies of RNA-binding protein biology, alternative splicing regulation, telomere maintenance by the hnRNP C-TERT axis, and the nuclear organisation of pre-mRNA processing complexes.