Anti-HNMT Antibody

From Antibodies.com, this polyclonal antibody targets human histamine N-methyltransferase (HNMT), the cytosolic enzyme that inactivates histamine by transferring a methyl group from S-adenosylmethionine to the imidazole ring of histamine. Supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the unconjugated reagent is validated for Western blot, immunohistochemistry, and immunofluorescence workflows. It cross-reacts with mouse and rat orthologues, supporting comparative studies across the most common mammalian model systems. Store aliquots frozen at -20°C and limit freeze-thaw cycles to preserve activity.

HNMT is broadly expressed in bronchial epithelium, liver, kidney, and neural tissue, and altered HNMT activity has been linked to asthma susceptibility, neurodegeneration, and inter-individual variation in drug clearance. Researchers use this reagent to localise HNMT in tissue sections, confirm expression in transfected cell lines, and follow changes in histamine-handling pathways under pharmacological or genetic perturbation. Each vial contains 100 µl of antibody, sufficient for multiple blotting or staining experiments when titred appropriately for the application.