Anti-HNF4A (phospho S304) Antibody

Produced in rabbit as a polyclonal IgG preparation, this unconjugated antibody specifically recognizes human hepatocyte nuclear factor 4 alpha (HNF4A) only when the protein is phosphorylated at serine 304. HNF4A is a nuclear receptor superfamily transcription factor that governs hepatocyte differentiation and the expression of genes controlling glucose, lipid, and amino acid metabolism, with loss-of-function variants linked to maturity-onset diabetes of the young type 1 (MODY1). The phospho-S304 epitope sits in the hinge region between the DNA-binding and ligand-binding domains, a modification reported to modulate DNA binding affinity, transactivation potential, and subcellular distribution of the receptor.

From Antibodies.com, the reagent is supplied at 200 µl in a vial and validated for Western blot detection of the phosphorylated receptor in human samples, supporting studies in liver biology, metabolic disease mechanisms, and diabetes research where site-specific phosphorylation state matters. The host species is rabbit, the isotype is IgG, and the conjugate is unconjugated for flexible secondary antibody pairing.