Anti-HNF4A Antibody

HNF4A (Hepatocyte Nuclear Factor 4 Alpha) is a nuclear receptor transcription factor critical for hepatocyte identity, hepatic gene regulation, and glucose and lipid metabolism. This rabbit polyclonal reagent from Antibodies.com is raised against HNF4A and supplied as 100 µl of unconjugated antibody suitable for western blot, immunohistochemistry, and immunofluorescence workflows. The antibody detects the human, mouse, and rat protein, enabling comparative studies of liver tissue, pancreatic islets, intestinal epithelium, and kidney, where HNF4A governs lineage-specific transcription programs. Investigators working on maturity-onset diabetes of the young (MODY1), hepatocellular carcinoma, or CYP450 enzyme regulation rely on HNF4A detection to map differentiation states and metabolic phenotypes in cultured cells and fixed sections. Aliquot upon arrival and store refrigerated to preserve binding activity across repeated experiments; avoid repeated freeze-thaw cycles to limit loss of titer. The polyclonal format offers broader epitope coverage than a monoclonal reagent, supporting robust signal across denaturing and native sample preparations and helping to buffer against minor lot-to-lot variation in target recognition.