Anti-HNF4α Antibody

Raised in rabbit against Hepatocyte Nuclear Factor 4 Alpha (HNF4α), this unconjugated polyclonal Primary Antibody from Antibodies.com is supplied at 1 mg/ml in Phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.2. The reagent has been validated for Western blot, immunohistochemistry, and immunofluorescence applications, and cross-reacts with Human, Mouse, and Rat samples. Each vial delivers 100 µL of antibody, sized for routine western blot, IHC, and IF staining runs on liver, intestinal, and pancreatic tissue preparations.

HNF4α is a nuclear receptor superfamily transcription factor that controls hepatocyte differentiation, intestinal epithelial maturation, and metabolic gene programs including gluconeogenesis, lipid transport, and CYP enzyme expression. Researchers use this antibody to map HNF4α distribution in liver tissue sections, characterize hepatic differentiation in induced pluripotent stem cell-derived hepatocyte models, and investigate disease contexts such as hepatocellular carcinoma, non-alcoholic fatty liver disease, maturity-onset diabetes of the young, and colorectal cancer. Store refrigerated and protect from light; aliquot on first use to limit freeze-thaw cycles and preserve activity across downstream assays.