Anti-HNF-4α / γ Antibody

Produced in rabbit, this polyclonal reagent from Antibodies.com is raised against HNF-4α and the closely related HNF-4γ isoform, two nuclear receptor transcription factors that govern hepatocyte differentiation, hepatic gene expression, and pancreatic beta-cell identity. The antibody is supplied as 100 µl of unconjugated antiserum in a vial and has been validated for Western blot and ELISA applications on human, mouse, and rat samples.

HNF-4α regulates transcription of genes involved in gluconeogenesis, bile acid synthesis, and lipid metabolism, making this reagent relevant for liver biology studies, type 2 diabetes mechanism research, MODY1-associated mutation analysis, and metabolic disease modeling. Investigators characterizing transcription factor networks in hepatic and intestinal epithelium, or probing developmental regulation of endoderm-derived tissues, can apply the antibody to track protein expression changes under experimental conditions.

As a polyclonal reagent, the antibody binds multiple epitopes on the HNF-4α target, supporting robust signal detection in denatured western blot workflows. Refrigerated storage between uses preserves binding activity for routine laboratory work.