Anti-HMGN1 Antibody

HMGN1 is a non-histone nucleosome-binding protein that modulates chromatin structure and influences transcription throughout the cell nucleus. This rabbit polyclonal reagent targets the human HMGN1 protein and is validated for Western blot and immunohistochemistry workflows. Supplied as 100 µl at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the unconjugated format allows researchers to pair the primary reagent with their preferred HRP or fluorophore-labeled secondary detection systems.

In Western blot applications, the antibody recognizes endogenous HMGN1 in whole-cell lysates, supporting studies of chromatin-associated factor expression across different cell types and treatment conditions. For immunohistochemistry, the reagent highlights nuclear HMGN1 distribution in formalin-fixed tissue sections, making it useful for examining chromatin organization in tumor and normal specimens.

HMGN1 has gained attention as a chromatin architectural protein with emerging roles in the DNA damage response and innate immune signaling, where it can function as an endogenous alarmin released during cell stress. Researchers studying gene regulation, nucleosome dynamics, or inflammation-related signaling pathways will find this antibody from Antibodies.com a useful tool for protein-level detection in human samples. The product contains 0.1% sodium azide as a preservative; refrigerate and protect from light to maintain reagent stability over time.