Anti-HMGCS1 Antibody

Produced by Antibodies.com, this rabbit polyclonal reagent targets 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (HMGCS1), the rate-limiting mitochondrial enzyme that condenses acetoacetyl-CoA with acetyl-CoA during ketogenesis and the mevalonate pathway leading to cholesterol biosynthesis. Supplied as 100 µl of unconjugated antiserum in a single vial, the antibody is validated for Western blot (WB) and immunohistochemistry (IHC) on human samples. Researchers apply it to studies of hepatic lipid metabolism, mitochondrial bioenergetics, and tumor metabolic reprogramming, where HMGCS1 expression is frequently investigated in cell lysates, tissue sections, and disease models linked to fatty-acid oxidation, ketone-body production, and statin-related pathway analysis. The unconjugated format supports both standard chemiluminescent WB workflows and chromogenic IHC protocols on formalin-fixed paraffin-embedded tissue. Intended for research use only, each preparation is raised in rabbit and recognizes the endogenous human HMG-CoA synthase protein under standard immunodetection conditions.