Anti-HMGCR Antibody

The HMGCR-targeting polyclonal reagent from Antibodies.com is a rabbit host antibody supplied as 100 µl of unconjugated serum suitable for Western blot and immunohistochemistry workflows. HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) catalyzes the rate-limiting step of the mevalonate pathway, converting HMG-CoA to mevalonate, and is the molecular target of statin-class cholesterol-lowering drugs. Researchers studying lipid biosynthesis, statin pharmacology, and metabolic disease use this reagent to monitor HMGCR expression in cultured cells and tissue sections. The antibody reacts with human, mouse, and rat samples, supporting translational studies that span rodent disease models and patient-derived material. Recommended applications include Western blot detection of endogenous HMGCR and immunohistochemical localization in formalin-fixed paraffin-embedded tissues, which is relevant to investigations of statin-associated immune-mediated necrotizing myopathy where anti-HMGCR autoantibodies are a recognized clinical biomarker. Store the vial at -20°C in working aliquots to limit freeze-thaw cycles, and protect from light until use.