Anti-HMGCL Antibody

The Anti-HMGCL Antibody from Antibodies.com is a rabbit polyclonal antibody targeting 3-Hydroxy-3-Methylglutaryl-CoA Lyase (HMGCL), a mitochondrial matrix enzyme that catalyzes the final reaction of ketogenesis and the terminal step of leucine catabolism.

Validated for Western blot (WB) and immunohistochemistry (IHC) applications, this unconjugated reagent reacts with human and mouse samples, supporting studies of fatty acid oxidation, ketone body biosynthesis, and inherited metabolic disorders such as HMG-CoA lyase deficiency, an autosomal recessive organic acidemia.

Supplied as 100 µl of polyclonal antibody raised in rabbit, the reagent enables detection of endogenous HMGCL protein in tissue sections and immunoblotting workflows, making it useful for researchers investigating mitochondrial enzyme function, peroxisomal and mitochondrial compartmentalization, and metabolic pathway regulation.

The unconjugated format allows flexibility with custom secondary antibody labeling for fluorescence, chromogenic, or HRP-based detection systems, accommodating both immunofluorescence microscopy of fixed tissue and standard chemiluminescent Western blot protocols depending on experimental needs.