Anti-HMGB3 Antibody

This rabbit polyclonal antibody targets HMGB3 (High Mobility Group Box 3), a chromatin-associated non-histone protein of the HMG-box family implicated in DNA replication, recombination, and transcriptional regulation. The unconjugated IgG reagent is raised in rabbit and supplied at 50 µl per vial, validated for western blot (WB) and immunohistochemistry (IHC) workflows across human, mouse, and rat samples. Researchers studying embryonic stem cell maintenance, lymphoid development, and HMGB3-linked oncology contexts such as acute myeloid leukemia use this reagent to detect endogenous HMGB3 levels in tissue lysates and fixed sections. Provided by Antibodies.com as a polyclonal primary antibody, the product supports detection pipelines where conserved epitope recognition across mammalian HMGB3 orthologues is required. The unconjugated format allows flexible pairing with secondary antibodies labeled to the user's preferred detection chemistry, including HRP, biotin, or fluorescent conjugates. Storage recommendations follow standard IgG conditions: keep the vial at –20 °C in working aliquots to preserve reagent integrity across multiple freeze-thaw cycles and to maintain batch-to-batch reproducibility.