Anti-HMG-1 Antibody

High Mobility Group Box 1 (HMGB1), a nuclear non-histone DNA-binding protein central to chromatin architecture, transcription control, and extracellular damage-associated signaling, is the target of this Rabbit polyclonal reagent from Antibodies.com.

The unconjugated preparation is supplied in a 100 µl vial and is validated for Western blot and ELISA across Human, Mouse, and Rat samples, supporting research into sepsis, sterile inflammation, autoimmunity, and tumor microenvironment biology.

Common applications include tracking HMGB1 nuclear-to-cytoplasmic translocation under cellular stress, quantifying release from necrotic cells, and probing HMGB1-mediated TLR4 and RAGE receptor signaling both in vitro and in vivo.

For best results, store the vial at -20 °C in single-use aliquots to limit freeze-thaw cycles and preserve antibody activity; protect from light and minimize time at room temperature.

Each lot is produced in a Rabbit host and affinity-purified to deliver batch-to-batch consistency for publication-grade immunodetection experiments.