Anti-HLA-F Antibody

Targeting the non-classical MHC class I molecule HLA-F, this rabbit polyclonal IgG reagent from Antibodies.com is supplied as a 100 µl vial of unconjugated antibody intended for Western blot application. The reagent shows species-specific reactivity with HLA-F in human and rat samples, supporting comparative studies of this major histocompatibility complex heavy chain across two model systems. HLA-F has gained research interest because, unlike classical HLA class I proteins, it can reach the cell surface in forms that lack or retain peptide cargo and engage a distinct set of immune receptors, including members of the KIR and ILT families on NK cells and myeloid cells. Applications include studies of reproductive immunology, viral infection models in rat systems, and tumor cell lines where altered HLA-F surface levels have been reported. The unconjugated format allows laboratories to couple the antibody to their own reporter of choice, such as HRP for chemiluminescent immunoblotting or a fluorophore for downstream imaging. For storage, aliquot upon arrival, refrigerate in the supplied buffer, and limit freeze-thaw cycles to preserve antibody activity over multiple experiments. The product is intended for research use only.