Anti-HLA-DRB4 Antibody

HLA-DRB4 is a class II major histocompatibility complex beta chain encoded within the DRB locus on chromosome 6, expressed on B lymphocytes, dendritic cells, and macrophages where it presents exogenous peptides to CD4-positive T cells. The DRB4 gene product is carried on haplotypes associated with the DR4, DR7, and DR9 serologic specificities, making it a useful marker for haplotype characterization and studies of antigen presentation.

This rabbit polyclonal IgG reagent is supplied unconjugated at a 50 µl volume by Antibodies.com and was raised against HLA-DRB4, with validation for Western blot detection in human and mouse samples. Researchers can use it to probe DRB4 expression in lymphoid tissue, transfected cell lines, or models of autoimmune inflammation where DR4-associated susceptibility has been reported. The polyclonal format offers broader epitope coverage than monoclonal reagents, supporting detection across denatured and reduced protein preparations typical of SDS-PAGE workflows. Aliquot upon receipt and store refrigerated to limit freeze-thaw cycles and preserve activity across repeated experiments.