Anti-HLA-DRB4 Antibody

Produced in rabbit as an unconjugated IgG polyclonal preparation, this HLA-DRB4 antibody from Antibodies.com supports Western blot detection of the major histocompatibility complex class II DRB4 beta chain. MHC class II molecules present extracellular antigens to CD4-positive T lymphocytes, and DRB4 expression patterns inform studies of antigen presentation, haplotype architecture, and immune regulation. Researchers working on rheumatoid arthritis associations, transplant matching, and autoimmunity models rely on this reagent to probe DRB4 protein levels in human and mouse samples.

Supplied as 200 µl of polyclonal antiserum in a single vial, the antibody recognizes the HLA-DRB4 target across human and mouse reactivity, with the rabbit host background compatible with standard immunoblotting workflows. The unconjugated format allows pairing with preferred secondary detection reagents, whether HRP chemiluminescence or fluorescence chemistries, depending on the imaging system available.

Recommended applications are restricted to Western blot; the reagent is not validated for immunohistochemistry, flow cytometry, or ELISA in the supplied documentation. Store refrigerated and avoid repeated freeze-thaw cycles to preserve antibody activity across multiple experiments. IgG isotype and polyclonal clonality support recognition of multiple epitopes on the DRB4 beta chain for consistent band detection in cell lysate and tissue homogenate preparations.