Anti-HLA-DPA1 Antibody

HLA-DPA1 encodes the alpha chain of the HLA-DP heterodimer, a Major Histocompatibility Complex class II molecule expressed on professional antigen-presenting cells including dendritic cells, B lymphocytes, and macrophages. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com is raised against recombinant and native human HLA-DPA1 and is validated for Western blot detection of the protein in cell lysates and tissue homogenates.

Each vial contains 50 µL of ready-to-use antibody. The reagent should be aliquoted upon arrival to minimise freeze-thaw cycles, then stored refrigerated and protected from light to preserve binding activity. Because HLA-DP differs from HLA-DR and HLA-DQ in its tissue distribution and peptide-loading compartment trafficking, this antibody distinguishes the alpha subunit of HLA-DP from related MHC class II chains, supporting work on antigen presentation, alloreactivity in transplantation, and the contribution of HLA-DP polymorphisms to chronic beryllium disease, sarcoidosis-like granulomatous disorders, and several autoimmune conditions such as rheumatoid arthritis and type 1 diabetes.

With confirmed reactivity to human HLA-DPA1, the antibody is routinely applied to characterise expression in B-lymphoblastoid cell lines and primary monocytes, and is intended for research use only.