Anti-Histone H4 (Tri-Methyl K20) Antibody

This rabbit polyclonal reagent from Antibodies.com specifically recognizes Histone H4 tri-methylated at lysine 20 (H4K20me3), a heterochromatin-associated epigenetic mark linked to transcriptional silencing, pericentric chromatin organization, and the DNA damage response. Supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as a 100 µl aliquot, the unconjugated antibody is validated for Western blot, immunohistochemistry, immunofluorescence, immunoprecipitation, chromatin immunoprecipitation (ChIP), and ChIP-seq workflows across human, mouse, and rat samples. The polyclonal format delivers strong signal amplification for detection of the trimethyl mark in chromatin extracts, fixed tissue sections, and immunoprecipitated nucleosomes, supporting studies of epigenetic regulation, cell cycle progression, genomic stability, and histone methylation dynamics in basic and translational research.