Anti-Histone H4 (Di-Methyl K20) Antibody

Histone H4 dimethylated at lysine 20 (H4K20me2) is a conserved epigenetic mark associated with chromatin compaction, the DNA damage response, and transcriptional silencing. The rabbit polyclonal antibody from Antibodies.com specifically recognizes this di-methyl modification on histone H4, enabling researchers to monitor H4K20me2 levels across multiple experimental systems.

Validated for Western blot, immunohistochemistry, immunofluorescence, immunoprecipitation, ChIP, and ChIP-seq workflows, the reagent offers flexibility for both targeted studies and genome-wide mapping. The unconjugated format allows downstream labeling with fluorophores, enzymes, or biotin depending on the detection chemistry required. Cross-reactivity with Human, Mouse, and Rat samples broadens utility for comparative studies in cell lines, primary tissues, and animal models.

Provided as a 100 µl volume at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the antibody is supplied as a ready-to-use stock suitable for aliquoting and storage at -20 °C. This polyclonal reagent from Antibodies.com is well suited for investigations into heterochromatin maintenance, replication-coupled chromatin assembly, and the epigenetic changes that accompany differentiation or genotoxic stress.