Anti-Histone H3 (Tri-Methyl K79) Antibody

Histone H3 trimethylation at lysine 79 (H3K79me3) is an epigenetic mark deposited by the methyltransferase DOT1L and associated with actively transcribed chromatin, gene-body methylation, and the DNA damage response. This unconjugated rabbit polyclonal reagent from Antibodies.com recognises the tri-methylated K79 residue on Histone H3 and is validated for western blot, immunohistochemistry, immunofluorescence, immunoprecipitation, and chromatin immunoprecipitation workflows, including ChIP-seq. The antibody is supplied as 100 µl at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol, which acts as a cryoprotectant and permits storage at -20 °C with resistance to repeated freeze-thaw cycles. Reactivity has been confirmed in human, mouse, and rat samples, supporting comparative studies of transcriptional regulation and epigenetic profiling across common model organisms.