Anti-Histone H3 (Tri-Methyl K4) Antibody

Raised in rabbit against a region of Histone H3 carrying the trimethylated lysine 4 mark (H3K4me3), this polyclonal reagent from Antibodies.com is supplied at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol, in a 100 µl pack size. H3K4me3 is an epigenetic modification concentrated at transcriptionally active promoters and CpG-rich islands, making this antibody a useful readout in chromatin and gene regulation studies.

The unconjugated antibody has been validated for Western blot, immunohistochemistry, immunofluorescence, immunoprecipitation, chromatin immunoprecipitation (ChIP), and ChIP-seq workflows, and it reacts with samples from human, mouse, and rat. Because lysine 4 trimethylation on the H3 tail is a defining feature of open, actively transcribed chromatin, the reagent is commonly used to map active promoters in stem cell biology, monitor differentiation programs, and characterize epigenetic changes in cancer research.

Shipped as a liquid in a glycerol-based cryostabilized buffer, this research-use-only reagent should be stored refrigerated and protected from light to preserve activity across multiple freeze-thaw cycles.