Anti-Histone H3 (phospho T11) Antibody

This rabbit polyclonal antibody from Antibodies.com recognizes histone H3 phosphorylated at threonine 11 (H3T11ph), a chromatin modification deposited by the Haspin (GSG2) kinase that supports chromosome alignment and segregation during mitosis. The unconjugated IgG reagent is supplied as 100 µL and is validated for Western blot detection of the modified histone in human, mouse, and rat samples. Researchers studying cell cycle progression, mitotic chromosome dynamics, or transcriptional regulation by post-translational histone modifications can probe acid-extracted lysates from proliferating cells, where H3T11 phosphorylation rises sharply during late G2 and mitosis. The polyclonal format gives broader recognition of epitopes surrounding the phospho-T11 site, useful for tracking drug responses that perturb mitotic kinase activity or chromatin-associated signaling in DNA damage pathways.