Anti-Histone H3 (Mono-Methyl K36) Antibody

Histone H3 mono-methylation at lysine 36 (H3K36me1) is an epigenetic modification linked to active transcription and enriched across gene bodies, making site-specific antibodies essential tools for chromatin biology research. This rabbit polyclonal reagent from Antibodies.com selectively recognizes the mono-methylated K36 residue on Histone H3, enabling researchers to distinguish this mark from di- and tri-methylated states. Validated across multiple platforms including Western blot, immunohistochemistry, immunofluorescence, immunoprecipitation, ChIP, and ChIP-seq, the antibody supports both targeted localization studies and genome-wide mapping approaches. It has been confirmed to react with Human, Mouse, and Rat samples, broadening its utility across standard model systems and primary cell work. Supplied as 100 µl at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the unconjugated format offers flexibility for direct immunolabeling or downstream conjugation. Researchers studying transcriptional elongation, chromatin remodeling, or histone methyltransferase activity will find this reagent well suited for probing methylation dynamics in cell culture and tissue-derived specimens.