Anti-Histone H3 (Di-Methyl K9) Antibody

Epigenetics research depends on reagents that faithfully recognize site-specific histone modifications. This unconjugated rabbit polyclonal antibody from Antibodies.com targets Histone H3 di-methylated at lysine 9 (H3K9me2), a chromatin mark linked to heterochromatin assembly, transcriptional silencing, and DNA methylation patterning. Supplied as 100 µl at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the reagent is validated for Western blot, immunohistochemistry, immunofluorescence, immunoprecipitation, chromatin immunoprecipitation, and ChIP-seq workflows across human, mouse, and rat samples. Investigators apply H3K9me2 profiling to studies of X-chromosome inactivation, genomic imprinting, retrotransposon repression, and aberrant silencing observed in cancer and developmental disease models. The polyclonal format provides tolerance for minor conformational variation around the modified residue, while the unconjugated presentation lets researchers pair it with their own secondary detection reagents and label of choice.