Anti-Histone H3 (Acetyl-K23) Antibody

A rabbit-derived polyclonal primary antibody from Antibodies.com that selectively recognizes histone H3 when acetylated at lysine 23 (H3K23ac), an epigenetic mark strongly associated with open, transcriptionally active chromatin. The reagent is supplied at 1 mg/ml in phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.2, packaged as a 100 µl vial sized for use across multiple experiments.

Validated for Western blot and immunofluorescence workflows and reactive against human, mouse, and rat samples, the antibody supports chromatin and gene regulation studies in both cell-based and tissue-based systems. Common research applications include profiling H3K23ac levels on acid-extracted histone preparations, tracking acetylation dynamics following HDAC inhibitor treatment, and mapping active chromatin regions by IF imaging.

For handling, store refrigerated and aliquot upon arrival to limit repeated freeze-thaw cycles, which can degrade polyclonal preparations over time. The unconjugated format and rabbit host allow direct pairing with standard anti-rabbit secondary reagents, while the polyclonal clonality promotes robust recognition of the modified lysine-23 epitope on histone H3.