Anti-Histone deacetylase 1 Antibody

Histone deacetylase 1 (HDAC1) is an epigenetic regulator belonging to the class I HDAC family. It removes acetyl groups from lysine residues on histone tails, condensing chromatin and repressing transcription at target gene loci. Laboratories studying chromatin remodeling, cell cycle progression, and lineage commitment across human, mouse, and rat models rely on Antibodies.com reagents to monitor this chromatin-modifying enzyme.

This unconjugated rabbit polyclonal reagent is provided as 50 µL of polyclonal antiserum, applied to Western blot detection of HDAC1, immunohistochemical localization in formalin-fixed tissue sections, immunofluorescence imaging of nuclear distribution patterns, and ELISA-based quantification of recombinant or endogenous HDAC1. Research groups investigating breast carcinoma, prostate cancer, colon carcinoma, and hematological malignancies, plus cardiac hypertrophy and neurodegenerative disease models, routinely profile HDAC1 expression to correlate epigenetic shifts with pathological progression.

Reactivity has been confirmed against human, mouse, and rat orthologs. The unconjugated format permits flexible coupling to horseradish peroxidase, fluorophores, or biotin for downstream detection chemistries. Refrigerated storage preserves antibody performance through repeated freeze-thaw cycles for longitudinal studies.