Anti-Histone 1.0 Antibody

This unconjugated rabbit polyclonal antibody from Antibodies.com targets Histone 1.0 (H1.0), a linker histone variant involved in higher-order chromatin folding and the stabilization of nucleosomal arrays. Produced in rabbit and supplied at 100 µL per vial, the reagent is validated for western blot, immunohistochemistry, and ELISA workflows, supporting studies in human samples where chromatin architecture, terminal cell differentiation, and gene silencing are of interest. The polyclonal format allows recognition of multiple epitopes across the H1.0 protein, which can be advantageous when probing conformational variants or post-translationally modified forms of the linker histone.

Histone H1.0 differs from the replication-dependent H1 subtypes in that its expression increases as cells exit the cell cycle and commit to differentiated states, making this reagent a useful marker in chromatin biology, epigenetic profiling, and investigations of long-term gene repression. Researchers studying nuclear organization, linker histone stoichiometry, or comparative analyses of H1 variants will find this antibody compatible with standard immunodetection protocols across a range of sample preparations.