Anti-Histamine H2 Receptor Antibody

Antibodies.com provides this unconjugated, rabbit polyclonal primary antibody for the human Histamine H2 Receptor, validated across Western blot, immunohistochemistry, and immunofluorescence workflows. Each vial delivers 100 µl of affinity-purified antiserum, enough reagent for multiple membrane blot exposures, fixed-tissue IHC sections, or IF staining runs on cultured cells.

The Histamine H2 Receptor is a Gs-coupled GPCR best known for mediating parietal cell gastric acid secretion, and it remains a relevant target in studies of gastrointestinal pharmacology, mast-cell biology, and signaling through the cAMP cascade. Researchers investigating receptor regulation, desensitization, or tissue distribution patterns use this reagent to confirm protein expression in transfected cell lines, primary gastric biopsies, and several human tumor-derived lines. The polyclonal format provides broader epitope coverage than monoclonal alternatives, supporting detection across multiple receptor domains even when single-epitope recognition is compromised by fixation or denaturation.

Storage and handling: refrigerate upon arrival; aliquot and store frozen for longer-term stability, and protect from light. Avoid repeated freeze-thaw cycles. The unconjugated format allows pairing with HRP-, biotin-, or fluorophore-conjugated secondary antibodies of the researcher's choice, supporting flexibility in assay design. Provided as a single-use vial format.