Anti-HIST4H4 Antibody

Histone H4 encoded by the HIST4H4 gene is a canonical core histone that packages genomic DNA into nucleosomes and acts as a major substrate for post-translational modifications governing chromatin state, transcription, and DNA repair. This unconjugated rabbit polyclonal reagent from Antibodies.com was raised against HIST4H4 and recognizes the corresponding histone H4 protein in human, mouse, and rat samples, supporting cross-species studies in epigenetics, chromatin biology, and gene regulation.

Validated for Western blot and immunohistochemistry, the antibody supports detection of total histone H4 in whole-cell lysates and visualization of nuclear staining patterns in formalin-fixed tissue sections. The polyclonal clonality broadens epitope coverage across the H4 sequence, an advantage when working with samples containing truncated or modified H4 variants. The unconjugated format allows pairing with a researcher's preferred secondary reagents and custom labeling strategies.

Supplied as 100 µl of liquid, the reagent is intended for research use only and is appropriate for studies of nucleosome assembly, histone modification crosstalk, and chromatin remodeling. Storage at 4°C short term with aliquoted freezing at -20°C preserves performance across multiple experiments.