Anti-HIST2H2BE Antibody

A rabbit polyclonal reagent from Antibodies.com raised against HIST2H2BE, a replication-coupled histone H2B variant incorporated into nucleosomes during S-phase chromatin assembly. Supplied as 100 µl of unconjugated antiserum formatted for Western blot and immunohistochemistry workflows on human, mouse, and rat samples. This antibody recognizes the histone H2B type 2-E protein and supports studies in chromatin biology, epigenetic regulation, DNA damage response, and tumor research where altered H2B expression patterns have been documented. Provided in a single vial without fluorophore, biotin, or enzyme conjugation, allowing researchers to pair the reagent with the secondary detection chemistry that best matches their assay. Typical uses include probing steady-state H2B pools in nuclear extracts, examining histone incorporation dynamics across the cell cycle, and visualizing chromatin organization in fixed tissue sections. The polyclonal format yields recognition of multiple epitopes on the target, which can strengthen signal when detecting post-translationally modified histone variants.