Anti-HIP1R Antibody

This polyclonal antibody from Antibodies.com specifically detects Huntingtin Interacting Protein 1-Related (HIP1R), a peripheral membrane protein that coordinates clathrin coat assembly with the actin cytoskeleton during clathrin-mediated endocytosis and receptor internalization.

Supplied as 200 µl of unconjugated rabbit polyclonal IgG, the reagent supports Western blot, immunohistochemistry, and flow cytometry workflows with human samples. The unconjugated format gives laboratories flexibility to conjugate their own fluorophores or enzymes, while polyclonal recognition of multiple HIP1R epitopes improves signal robustness across varied sample preparations.

HIP1R serves as a scaffold that links clathrin-coated pits to actin filaments through interactions with cortactin and other cytoskeletal components, and it has been investigated in the context of huntingtin biology, synaptic vesicle recycling, and growth factor receptor trafficking in cancer cell lines. Researchers commonly deploy the antibody to confirm protein expression in cell lysates by Western blot, map subcellular localization in fixed tissue by immunohistochemistry, and characterize HIP1R-positive populations by flow cytometry.

For handling, aliquot the antibody upon receipt to limit freeze-thaw cycles, and store refrigerated to preserve IgG activity across long-term use. Each vial is intended for research use only and is reactive with human HIP1R.