Anti-HIF1A Antibody

This polyclonal IgG antibody from Antibodies.com targets the hypoxia-inducible transcription factor HIF-1α, a key regulator of cellular adaptation to low oxygen conditions. Raised in rabbit and supplied unconjugated, the reagent is provided in a 100 µl volume and validated for western blot applications across human, mouse, and rat samples.

HIF-1α is widely studied in oncology, cardiovascular biology, and metabolic disease research, where investigators track its stabilization under hypoxic stress or its accumulation in tumor microenvironments. The antibody's cross-species reactivity makes it useful for comparative studies between rodent disease models and human clinical specimens, supporting translational work on angiogenesis, glycolytic reprogramming, and ischemia-related pathways.

For western blot, samples are typically lysed under conditions that preserve the labile HIF-1α protein, and hypoxic induction can be confirmed using appropriate positive controls. Store refrigerated and protect from light to maintain reagent performance across multiple experiments.