Anti-HICE1 Antibody

The HICE1 protein (HECT, UBA and WWE domain-containing protein 1, also known as HUWE1) is a large multi-domain E3 ubiquitin ligase that targets substrates such as p53, Mcl-1, and c-Myc for proteasomal degradation, linking it to apoptosis regulation, DNA damage response, and tumor suppression pathways. This unconjugated rabbit polyclonal antibody from Antibodies.com is supplied as a 100 µl liquid aliquot and binds the endogenous human HICE1 protein for research use only in western blot, immunohistochemistry, and immunofluorescence workflows. Validated reactivity is specific to human samples, and the polyclonal format gives broader epitope coverage than monoclonal alternatives. For short-term use, store aliquots refrigerated at 4 degrees C; for long-term storage, freeze at -20 degrees C and limit freeze-thaw cycles to preserve antibody activity. The unconjugated format lets researchers pair the reagent with their own secondary antibody or fluorescent label, and the product is packaged as a single vial ready to dilute into standard immunostaining or lysis buffers.